Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
Identifieur interne : 004101 ( Main/Exploration ); précédent : 004100; suivant : 004102Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
Auteurs : Dusan Bartsch [États-Unis] ; Mirella Ghirardi [États-Unis] ; Paul A. Skehel [États-Unis] ; Kevin A. Karl [États-Unis] ; Susan P. Herder [États-Unis] ; Mary Chen [États-Unis] ; Craig H. Bailey [États-Unis] ; Eric R. Kandel [États-Unis]Source :
- Cell [ 0092-8674 ] ; 1995.
English descriptors
- Teeft :
- Activator, Amino, Amino acids, Antiserum, Apclebp, Apcreb2, Apcreb2 antiserum, Apcreb2 antiserum injection, Apcreb2 protein, Apcrebl, Apcrebp, Apcrebp antiserum, Apcrfbp mrna, Aplysia, Assay, Atf4, Bailey, Bzlp, Bzlp domain, Castellucci, Catalytic subunit, Cdna, Cell culture, Cocultures, Control cells, Control cultures, Cotransfected, Crebl, Crebp, Drosophila, Epsp, Epsp amplitude, Facilitation, Flashbulb memories, Fusion protein, Fusion proteins, Ghirardi, Glanzman, Human crebp, Immune, Immune serum, Independent clones, Inhibitor, Injection, Kandel, Kinase, Leucine, Luciferase, Luciferase activity, Messenger pathways, Montarolo, Motor cell, Motor neuron, Mouse atf4, Mrna, Multiple bands, Neuron, Normal rabbit serum, Pathway, Percent change, Percentage change, Phosphatase, Photographic memory, Plasmid, Preimmune, Preimmune serum, Promoter, Protein synthesis, Protein synthesis inhibitor anisomycin, Pulse, Recombinant, Recombinant apcreb2, Recombinant apcrebp, Relative activation, Reporter gene, Represses, Repressor, Sensitization, Sensory neuron, Sensory neuron varicosities, Sensory neurons, Significant facilitation, Single pulse, Structural changes, Synaptic, Synaptic connections, Time course, Training trials, Transactivation, Transcription, Transcription factor, Transcription factors, Transcriptional, Varicosity, Western blot, Western blots, Zipper.
Abstract
Abstract: The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.
Url:
DOI: 10.1016/0092-8674(95)90213-9
Affiliations:
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Herder</name></author><author><name sortKey="Chen, Mary" sort="Chen, Mary" uniqKey="Chen M" first="Mary" last="Chen">Mary Chen</name></author><author><name sortKey="Bailey, Craig H" sort="Bailey, Craig H" uniqKey="Bailey C" first="Craig H." last="Bailey">Craig H. Bailey</name></author><author><name sortKey="Kandel, Eric R" sort="Kandel, Eric R" uniqKey="Kandel E" first="Eric R." last="Kandel">Eric R. 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Skehel</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032</wicri:regionArea><wicri:noRegion>New York 10032</wicri:noRegion></affiliation></author><author><name sortKey="Karl, Kevin A" sort="Karl, Kevin A" uniqKey="Karl K" first="Kevin A." last="Karl">Kevin A. Karl</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032</wicri:regionArea><wicri:noRegion>New York 10032</wicri:noRegion></affiliation></author><author><name sortKey="Herder, Susan P" sort="Herder, Susan P" uniqKey="Herder S" first="Susan P." last="Herder">Susan P. Herder</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032</wicri:regionArea><wicri:noRegion>New York 10032</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Mary" sort="Chen, Mary" uniqKey="Chen M" first="Mary" last="Chen">Mary Chen</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032</wicri:regionArea><wicri:noRegion>New York 10032</wicri:noRegion></affiliation></author><author><name sortKey="Bailey, Craig H" sort="Bailey, Craig H" uniqKey="Bailey C" first="Craig H." last="Bailey">Craig H. Bailey</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032</wicri:regionArea><wicri:noRegion>New York 10032</wicri:noRegion></affiliation></author><author><name sortKey="Kandel, Eric R" sort="Kandel, Eric R" uniqKey="Kandel E" first="Eric R." last="Kandel">Eric R. Kandel</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032</wicri:regionArea><wicri:noRegion>New York 10032</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="ISSN">0092-8674</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">83</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="979">979</biblScope><biblScope unit="page" to="992">992</biblScope></imprint><idno type="ISSN">0092-8674</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0092-8674</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Activator</term><term>Amino</term><term>Amino acids</term><term>Antiserum</term><term>Apclebp</term><term>Apcreb2</term><term>Apcreb2 antiserum</term><term>Apcreb2 antiserum injection</term><term>Apcreb2 protein</term><term>Apcrebl</term><term>Apcrebp</term><term>Apcrebp antiserum</term><term>Apcrfbp mrna</term><term>Aplysia</term><term>Assay</term><term>Atf4</term><term>Bailey</term><term>Bzlp</term><term>Bzlp domain</term><term>Castellucci</term><term>Catalytic subunit</term><term>Cdna</term><term>Cell culture</term><term>Cocultures</term><term>Control cells</term><term>Control cultures</term><term>Cotransfected</term><term>Crebl</term><term>Crebp</term><term>Drosophila</term><term>Epsp</term><term>Epsp amplitude</term><term>Facilitation</term><term>Flashbulb memories</term><term>Fusion protein</term><term>Fusion proteins</term><term>Ghirardi</term><term>Glanzman</term><term>Human crebp</term><term>Immune</term><term>Immune serum</term><term>Independent clones</term><term>Inhibitor</term><term>Injection</term><term>Kandel</term><term>Kinase</term><term>Leucine</term><term>Luciferase</term><term>Luciferase activity</term><term>Messenger pathways</term><term>Montarolo</term><term>Motor cell</term><term>Motor neuron</term><term>Mouse atf4</term><term>Mrna</term><term>Multiple bands</term><term>Neuron</term><term>Normal rabbit serum</term><term>Pathway</term><term>Percent change</term><term>Percentage change</term><term>Phosphatase</term><term>Photographic memory</term><term>Plasmid</term><term>Preimmune</term><term>Preimmune serum</term><term>Promoter</term><term>Protein synthesis</term><term>Protein synthesis inhibitor anisomycin</term><term>Pulse</term><term>Recombinant</term><term>Recombinant apcreb2</term><term>Recombinant apcrebp</term><term>Relative activation</term><term>Reporter gene</term><term>Represses</term><term>Repressor</term><term>Sensitization</term><term>Sensory neuron</term><term>Sensory neuron varicosities</term><term>Sensory neurons</term><term>Significant facilitation</term><term>Single pulse</term><term>Structural changes</term><term>Synaptic</term><term>Synaptic connections</term><term>Time course</term><term>Training trials</term><term>Transactivation</term><term>Transcription</term><term>Transcription factor</term><term>Transcription factors</term><term>Transcriptional</term><term>Varicosity</term><term>Western blot</term><term>Western blots</term><term>Zipper</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Bartsch, Dusan" sort="Bartsch, Dusan" uniqKey="Bartsch D" first="Dusan" last="Bartsch">Dusan Bartsch</name></noRegion><name sortKey="Bailey, Craig H" sort="Bailey, Craig H" uniqKey="Bailey C" first="Craig H." last="Bailey">Craig H. Bailey</name><name sortKey="Chen, Mary" sort="Chen, Mary" uniqKey="Chen M" first="Mary" last="Chen">Mary Chen</name><name sortKey="Ghirardi, Mirella" sort="Ghirardi, Mirella" uniqKey="Ghirardi M" first="Mirella" last="Ghirardi">Mirella Ghirardi</name><name sortKey="Herder, Susan P" sort="Herder, Susan P" uniqKey="Herder S" first="Susan P." last="Herder">Susan P. Herder</name><name sortKey="Kandel, Eric R" sort="Kandel, Eric R" uniqKey="Kandel E" first="Eric R." last="Kandel">Eric R. Kandel</name><name sortKey="Karl, Kevin A" sort="Karl, Kevin A" uniqKey="Karl K" first="Kevin A." last="Karl">Kevin A. Karl</name><name sortKey="Skehel, Paul A" sort="Skehel, Paul A" uniqKey="Skehel P" first="Paul A." last="Skehel">Paul A. Skehel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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